 |
Shannon R. Magari, ScD, MS, MPH,
|
Education
- Harvard University, 2001
Doctor of Science, ScD Environmental Health, concentration Occupational Epidemiology from the School of Public Health. Thesis, "Cardiovascular Responses to Occupational and Environmental Particulate Matter." The first prospective study of occupational and environmental particulates to utilize personal monitoring to examine preclinical changes in cardiovascular autonomic function in a young working cohort. Utilized a repeated measures design in this cohort to analyze minute to minute exposure and response relationships to reveal significant decreases in parasympathetic tone associated with increases in particulate exposure. - Boston University, 1997
Master of Public Health, MPH, concentration Epidemiology and Biostatistics from the School of Public Health - Dartmouth College, 1994
Master of Science, MS Engineering Science, concentration Chemical Engineering from the Thayer School of Engineering. Thesis, "In vitro Regeneration of Articular Cartilage in a Novel Bioreactor". Designed, constructed, characterized and operated a novel bioreactor for the in vitro tissue engineering of articular cartilage. - Syracuse University, 1992
Bachelor of Science, BS Bioengineering from the LC Smith School of Engineering.
Professional Experience
Colden Corporation
Senior Scientist and Vice President of Health Sciences 2002 - present
Providing the following:
- Epidemiologic analyses- research and critical evaluation of the medical, scientific and epidemiologic literature to aid in the determination of causation for environmentally and occupationally derived health concerns
- Litigation support and case development, see detailed select experience
- Statistical data analyses, biostatistics
- Occupational and environmental exposure assessment
- Risk communication
- Indoor environmental quality studies
- Biosafety program development
Harvard University
National Research Service Award trainee 1997-2001
Postdoctoral Research Fellow 2001-2002
Visiting Scientist 2002-Present
Work throughout the tenure has been in the Occupational Epidemiology Program including:
- Responsible for all phases of a short-term prospective epidemiologic study investigating the effects of particulate air pollution on the cardiovascular system. This included study design, development, laboratory and project staff management.
- Designed relational databases and performed all statistical programming and interpretation using SAS and Splus.
- Teaching and curriculum development were also performed in basic environmental health, epidemiology and occupational health policy.
- Served as laboratory health and safety director to ensure compliance with university regulations.
Ariad Pharmaceuticals
Associate Research Scientist 1994 - 1997
In the toxicology department, supported several discovery avenues including allergy, asthma, osteoporosis and regulated gene therapy products.
- Designed, tested and analyzed pharmacokinetic, bioavailability and preliminary investigative toxicology studies.
- Developed analytical chemistry methods for these studies using HPLC and MS.
- Developed tissue culture and assay methods for the analysis of bone resorption for an in vitro osteoporosis model.
Dartmouth College
Research Assistant 1992-1994
- Designed, constructed, characterized and operated a novel bioreactor for the in vitro tissue engineering of articular cartilage in a three dimensional environment.
- Tested various biomaterial matrices within the reactor and developed chemical assays to monitor chondrocyte function and articular cartilage regeneration in the reactor.
Bristol-Myers Squibb
Intern Health and Safety summer 1998
Intern Process Engineer 1989 - 1992
Dr. Magari served as an intern in both the fermentation and health and safety departments in their Upstate New York manufacturing facility.
In the health and safety department:
- Conducted health hazards analyses of bioaerosol exposures in a wastewater treatment facility including a preliminary risk analysis, industrial hygiene sampling and recommendations for protective action.
- Developed and implemented a drinking water sampling and analysis plan for the site.
- Initiated a personal protective equipment review for electrical shop personnel, and made and implemented appropriate safety recommendations.
In the fermentation department:
- Performed engineering analysis of heat transfer, mass transfer and power uptake for biochemical fermentation processes.
- Responsible for tracking, compiling and publishing detailed production engineering reports for weekly and monthly periods.
- Performed engineering and cost analysis of proposals for modification and implementation of operating procedures.
- Responsible for software updating, documentation and training of chemical process operators with new computer control systems.
Select Litigation Support Consulting Project Experience
Mass and Toxic Torts
Evaluate relevant epidemiologic and medical literature to aid in case development and strategy. Direct the development and population of relational databases including demographic, medical and exposure assessment data to establish and track occupational and environmental cohorts for statistical analyses. Performed statistical analyses to determine the relevance of cluster theory arguments including identification of appropriate control and comparison populations. Aid in the identification and qualification of other experts and the generation of counsel's scientific exhibits.
Litigation Support Provided to In House Counsel
Define cohort inclusion criteria and evaluate disease prevalence and rates among effected employees with identification of appropriate control and comparison groups. Perform in depth exposure assessments in complex occupational settings. Determine hazard profiles for given health outcomes in the cohort. Develop exposure assessment strategies and perform industrial hygiene monitoring for a range of toxicants including dusts, hydrocarbons, heavy metals and other inorganic compounds. Critical evaluation of gathered data, development of individual dose estimates and consideration of their association with purported health effects. Conduct individual and group risk communication meetings to outline cohort questions and concerns, convey strategies to address stakeholders concerns and relay results and follow-up action plans.
Workers Compensation
Provide critical evaluation of the relevant medical and epidemiologic literature. Review and critique opposing expert's testimony to aid in development of cross examination strategy. Determine relevancy of purported occupational hazard to outcomes of concern. Perform industrial hygiene testing to aid in the development of counsel's argument.
Professional Organizations
- International Society for Environmental Epidemiology
- American Industrial Hygiene Association
- American Public Health Association
- Biomedical Engineering Society, Co-Chair Dartmouth Chapter (1993-1994)
- Society of Women Engineers
- Order of the Engineer
Presentations/Published Abstracts
Magari, S.R., Schwartz, J., Williams, P., Hauser, R., Smith, T.J., Christiani, D.C., The Association of Particulate Air Metal Concentrations with Heart Rate Variability, American Journal of Epidemiology, Vol. 155, No. 11, pp 309 Suppl. S, 2002.
Magari, S.R., Schwartz, J., Williams, P., Hauser, R., Smith, T.J., Christiani, D.C., Association of Personal Particle Exposure with Heart Rate Variability, Epidemiology, Vol. 12, No. 4, pp S39, 2001. International Society of Environmental Epidemiology, Garmisch, Germany, 2001.
Magari, S.R., Hauser, R., Smith, T.J., Schwartz, J., Williams, P., Christiani, D.C., Association of Heart Rate Variability with Occupational and Environmental Exposure to Particulates. Seventh International Congress on Combustion By-Products, North Carolina, 2001.
Kim, J.Y., Magari, S.R., Christiani, D.C., Exhaled Nitric Oxide Measurements in Workers Exposed to Fuel-Oil Ash, American Journal of Respiratory and Critical Care Medicine, Vol. 163, No. 5, pp A494 2001. American Thoracic Society, San Francisco, 2001.
Mukherjee, S., Rodrigues, E., Magari, S.R., Kim, J.Y., Weker, R., Chrisitiani, D.C. Urinary 1-Hydroxypyrene As A Biomarker of Exposure to Airborne Polycyclic Aromatic Hydrocarbons in Boilermakers, American Journal of Respiratory and Critical Care Medicine, Vol.163, No.5, pp A495, 2001, American Thoracic Society, San Francisco, 2001.
Mukherjee, S., Rodrigues, E., Magari, S.R., Kim, J.Y., Weker, R., Chrisitiani, D.C. Assessment of Urinary 1-Hydroxypyrene Level as a Biomarker of Polycyclic aromatic Hydrocarbon (PA) Exposure in Occupationally Exposed Boilermakers, Epidemiology, Vol.12, No. 4, pp 174, 2001.
Magari, S.R., Woodin, M., Hauser, R., Smith, T.J., Schwartz, J., Williams, P., Christiani, D.C., Cardiovascular Effects of Exposure to Fuel-Oil Ash and Metal Fume: A Preliminary Assessment. American Journal of Respiratory and Critical Care Medicine, Vol. 161, No. 3, pp. A25, American Thoracic Society, Toronto, Canada, 2000.
Kim, J.Y., Magari, S.R., Herrick, R.F., Smith, T.J., Christiani, D.C., Comparison of PM2.5 Measurements from a Direct-Reading Instrument and a Gravimetric Sampling Method, American Industrial Hygiene Conference, 2000.
Fine, E.G., Magari, S.R., Rousseau, S., Orndorff, K. A., Heath, C.A., and Rosen, J. M., Chondrocytes Grown on Opaque Porous Biodegradable Polymer Matrices Examined by Confocal Microscopy, 20th Annual Mtg., Society for Biomaterials, Boston, MA, April 1994.
Magari, S.R. and Heath, C.A., In Vitro Chondrocyte Growth and Cartilage Formation Under Intermittent Hydrostatic Pressure, Engineering Foundation Conference, Cell Culture Engineering IV, San Diego, CA, March 1994.
Magari, S.R. and Heath, C.A., Chondrocyte Growth and Cartilage Formation in a Three-Dimensional Resorbable Matrix under Intermittent Hydrostatic Pressure, U.K.-U.S. Workshop on Cellular Engineering, Chester, England, September 1993.
Publications
Magari, S.R., Schwartz, J., Williams, P.L., Hauser, R., Smith, T.J., Christiani, D.C., The Association of Particulate Air Metal Concentrations With Heart Rate Variability, Environmental Health Perspectives, Vol. 110, No. 9, 875-880, 2002.
Magari, S.R., Schwartz, J., Williams, P.L., Hauser, R., Smith, T.J., Christiani, D.C., The Association Between Personal Measurements of Environmental Exposure to Particulates and Heart Rate Variability, Epidemiology, Vol. 13, pp 305-310, 2002.
Magari, S.R., Hauser, R., Schwartz, J., Williams, P.L., Smith, T.J., Christiani, D.C., The Association of Heart Rate Variability with Occupational and Environmental Exposure to Particulate Air Pollution, Circulation, Vol. 104, 986-991, 2001.
Clackson, T., Yang, W., Rozamus, L.W., Hatada, M., Amara, J.F., Rollins, C.T., Stevenson, L.F., Magari, S.R., Wood, S.A., Courage, N.L., Lu, X., Cerasoli, F., Gilman, M. and Holt, D.A., Redesigning an FKBP-ligand Interface to Generate Chemical Dimerizers with Novel Specificity, Proceedings of the National Academy of Sciences, Vol. 95, 10437-10442, 1998.
Magari, S.R., Rivera, V.M., Iuliucci, J.D., Gilman, M., and Cerasoli F., Pharmacologic Control of a Humanized Gene Therapy System Implanted in to Nude Mice, Journal of Clinical Investigations, Vol. 100, No. 11, pp. 2865-2872, 1997.
Rivera, V.M., Clackson, T., Natesan, S., Pollock, R., Amara, J. Keenan, T., Magari, S.R., Phillips, T., Courage, N.L., Cerasoli, F., Holt, D.A., and Gilman, M., A Humanized System for Pharmacologic Control of Gene Expression, Nature Medicine, Vol. 2, No. 9, pp. 1028-1032, 1996.
Heath, C.A. and Magari, S.R., Mini-Review: Mechanical Factors Affecting Cartilage Regeneration In Vitro, Biotechnology and Bioengineering, Vol. 51, pp. 430-437, 1996.